Edward Preble Little (1791-11-07 – 1875-02-06) was a member of the United States House of Representatives from Massachusetts. He was born in Marshfield on November 7, 1791. He attended public schools. At the age of nine (in 1800) he was on the U.S. frigate Boston with his father, Capt. George Little, at the suggestion of President John Adams, who gave him a commission as midshipman. He engaged in agricultural pursuits.
Little served as a member of the Massachusetts House of Representatives and was elected as a Democrat to the Thirty-second Congress to fill the vacancy caused by the death of Orin Fowler. He served from December 13, 1852 to March 3, 1853. He was not a candidate for renomination to the Thirty-third Congress, but served as collector of customs at the port of Plymouth.
Little resumed agricultural pursuits, and died in Lynn, Massachusetts on February 6, 1875. His interment was in the Congregational Church Cemetery in Marshfield Hills.